![]() Multivariate analyses showed independently and significantly decreased free T 4 (FT 4) × TSH with increasing non- ortho PCBs ( r = −0.2 p < 0.05). ![]() Insulin-like growth factor (IGF)-1, IGF-binding globulin-3, and thyroxine × yroid-stimulating hormone (T 4 × TSH) were significantly associated with increased placental weight and Quetelet index (in kilograms per square meter correlation coefficient r = 0.2–0.3 p < 0.05). We analyzed thyroid and growth hormones from cord serum using radioimmunoassay. We analyzed placentas for 17 polychlorinated dibenzo- p-dioxins and dibenzofurans and 12 dioxin-like PCB congeners with the World Health Organization–defined toxic equivalent factors, and six indicator PCBs by high-resolution gas chromatography and high-resolution mass spectrometry. Clinicians gathered placental and umbilical cord serum upon delivery and carefully scored the 118 newborns, making both structural and functional assessments. Personal data collected included reproductive and medical histories and physical factors. We recruited 118 pregnant women, between 25 and 34 years of age, at the obstetric clinic. The aim of this study is to examine the association between transplacental exposure to dioxins/polychlorinated biphenyls (PCBs) and thyroid and growth hormones in newborns.
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